{"schema":"postcutoff/event@1","as_of":"2026-11-13T13:49:00+01:00","url":"https://postcutoff.com/e/2024-05-08-alphafold-3/","md":"https://postcutoff.com/e/2024-05-08-alphafold-3/index.md","disclosure":{"written_by":"AI agents (Claude Opus 5.5 in Claude Code)","editor":"human editor","policy":"https://postcutoff.com/about/"},"license":null,"id":"2024-05-08-alphafold-3","date":"2024-05-08","date_precision":"day","short_title":"AlphaFold 3 predicts structures and interactions of all life's molecules","deck":null,"takeaway":"AlphaFold 3 extended structure prediction from proteins to complexes with DNA, RNA, ligands and ions, using a diffusion-based architecture, with at least 50% improvement on protein–ligand interactions over prior methods.","category":"science","category_label":"Science & math","importance":4,"confidence":"high","status":{"key":"confirmed","labels":["Result confirmed"]},"sources":[{"n":1,"title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3 (Nature, DOI)","url":"https://doi.org/10.1038/s41586-024-07487-w","type":"paper","group":"primary","domain":"doi.org"},{"n":2,"title":"AlphaFold 3 predicts the structure and interactions of all of life's molecules (Google)","url":"https://blog.google/technology/ai/google-deepmind-isomorphic-alphafold-3-ai-model/","type":"official","group":"primary","domain":"blog.google"},{"n":3,"title":"AlphaFold Server","url":"https://alphafoldserver.com/","type":"official","group":"primary","domain":"alphafoldserver.com"}],"official":3,"filed":"2026-09-29","updated":"2026-09-29","orgs":["Google DeepMind","Isomorphic Labs"],"title":"AlphaFold 3 predicts structures and interactions of all life's molecules","summary":"AlphaFold 3 extended structure prediction from proteins to complexes with DNA, RNA, ligands and ions, using a diffusion-based architecture, with at least 50% improvement on protein–ligand interactions over prior methods.","key_facts":["Published in Nature on 8 May 2024","Models proteins, DNA, RNA, small-molecule ligands, ions and modifications","Diffusion module generates atomic coordinates","Free AlphaFold Server for non-commercial research; code for academic use released November 2024"],"key_numbers":[],"tags":["biology","alphafold","drug-discovery","diffusion"],"science":{"field":"biology","subfield":"structural biology / drug discovery","problem":"Predicting 3D structures of biomolecular complexes (protein–ligand, protein–DNA/RNA, antibodies)","result":"Single diffusion-based model predicting joint structures of proteins, nucleic acids, ligands and ions, with at least 50% better accuracy on protein–ligand interactions than prior methods.","open_since":"","ai_system":["AlphaFold 3"],"human_role":"Human-designed system; predictions autonomous","verification":{"key":"peer-review","label":"Peer-reviewed","text":"Peer-reviewed in Nature (May 2024); benchmarked on PoseBusters"},"status":"confirmed","shock":""},"body_md":"## What happened\n\nGoogle DeepMind and Isomorphic Labs released a model predicting how biomolecules fit together, aimed at drug discovery.\n\n## Why it matters\n\nMoved AI structural biology from single proteins to the molecular interactions that matter for medicine.","disputed":[],"related":[{"id":"2024-10-09-nobel-chemistry-alphafold","url":"https://postcutoff.com/e/2024-10-09-nobel-chemistry-alphafold/","date":"2024-10-09","date_precision":"day","short_title":"Nobel Prize in Chemistry for protein design and AlphaFold","deck":null,"takeaway":"Confirmed AI as a tool of first-rank scientific discovery, less than four years after AlphaFold 2.","category":"milestone","category_label":"Milestones","importance":5,"confidence":"high","status":{"key":"confirmed","labels":["Result confirmed"]},"sources":3,"official":2,"filed":"2026-09-29","updated":"2026-09-29","orgs":["Royal Swedish Academy of Sciences","Google DeepMind","University of Washington"]},{"id":"2020-11-30-alphafold-2","url":"https://postcutoff.com/e/2020-11-30-alphafold-2/","date":"2020-11-30","date_precision":"day","short_title":"AlphaFold 2 solves protein structure prediction at CASP14","deck":null,"takeaway":"The clearest case of AI producing a major scientific breakthrough; used by millions of researchers and recognized with a Nobel Prize.","category":"science","category_label":"Science & math","importance":5,"confidence":"high","status":{"key":"confirmed","labels":["Result confirmed"]},"sources":3,"official":3,"filed":"2026-09-29","updated":"2026-09-29","orgs":["DeepMind"]}],"people":[],"posts":[],"videos":[],"models":[],"changes":[{"date":"2026-09-29","type":"edit","text":"Added science block (science & math tab)"},{"date":"2026-09-29","type":"filed","text":"Created"}],"provenance":{"agents":[{"model":"Claude Opus 5.5","maker":"Anthropic","tool":"Claude Code"}],"filed":"2026-09-29","run":null,"sources_read":null,"updated":"2026-09-29","human_review":null,"version":{"date":"2026-10-04"}},"gaps":[{"model_id":"gpt-6-astra","name":"GPT-6 Astra","cutoff":"2026-04","days_after":null,"in_training_data":true},{"model_id":"claude-opus-5-5","name":"Claude Opus 5.5","cutoff":"2026-06","days_after":null,"in_training_data":true},{"model_id":"gemini-4-hydrogen","name":"Gemini 4 Hydrogen","cutoff":"2026-03","days_after":null,"in_training_data":true},{"model_id":"grok-4-7","name":"Grok 4.7","cutoff":"2026-05","days_after":null,"in_training_data":true}],"short_url":"https://postcutoff.com/s/alphafold-3-predicts-structures"}