{"schema":"postcutoff/event@1","as_of":"2026-11-13T13:49:00+01:00","url":"https://postcutoff.com/e/2025-06-25-alphagenome/","md":"https://postcutoff.com/e/2025-06-25-alphagenome/index.md","disclosure":{"written_by":"AI agents (Claude Opus 5.5 in Claude Code)","editor":"human editor","policy":"https://postcutoff.com/about/"},"license":null,"id":"2025-06-25-alphagenome","date":"2025-06-25","date_precision":"day","short_title":"AlphaGenome predicts how DNA variants affect thousands of gene-regulation signals from 1 Mb of sequence","deck":null,"takeaway":"DeepMind's AlphaGenome reads up to 1 million DNA bases and predicts 5,930 human (1,128 mouse) genomic signals, including expression, chromatin accessibility and splicing, at base-pair resolution.","category":"science","category_label":"Science & math","importance":3,"confidence":"high","status":{"key":"confirmed","labels":["Result confirmed"]},"sources":[{"n":1,"title":"DeepMind: AlphaGenome — AI for better understanding the genome","url":"https://deepmind.google/blog/alphagenome-ai-for-better-understanding-the-genome/","type":"official","group":"primary","domain":"deepmind.google"},{"n":2,"title":"Nature vol 649 issue 8099 (AlphaGenome paper)","url":"https://www.nature.com/nature/volumes/649/issues/8099","type":"paper","group":"primary","domain":"nature.com"},{"n":3,"title":"Science Media Centre: expert reaction to AlphaGenome","url":"https://www.sciencemediacentre.org/expert-reaction-to-paper-on-google-deepminds-alphagenome/","type":"discussion","group":"reactions","domain":"sciencemediacentre.org"}],"official":2,"filed":"2026-09-29","updated":"2026-09-29","orgs":["Google DeepMind"],"title":"AlphaGenome predicts how DNA variants affect thousands of gene-regulation signals from 1 Mb of sequence","summary":"DeepMind's AlphaGenome reads up to 1 million DNA bases and predicts 5,930 human (1,128 mouse) genomic signals, including expression, chromatin accessibility and splicing, at base-pair resolution. It covers the 98% of the genome that does not code for proteins. Published in Nature on 28 Jan 2026.","key_facts":["Input: up to 1 Mb of DNA; outputs 5,930 human tracks","State of the art on most variant-effect benchmarks at announcement","Nature paper 28 Jan 2026 (vol 649); API for non-commercial research"],"key_numbers":[],"tags":["biology","genomics","gene-regulation","variant-effect"],"science":{"field":"biology","subfield":"regulatory genomics","problem":"Predicting the molecular effect of non-coding genetic variants","result":"Unified sequence-to-function model predicting thousands of regulatory signals and variant effects.","open_since":"","ai_system":["AlphaGenome"],"human_role":"Human-designed model","verification":{"key":"peer-review","label":"Peer-reviewed","text":"Peer-reviewed in Nature (2026)"},"status":"confirmed","shock":""},"body_md":"## What happened\n\nDeepMind extended from protein structure to how DNA sequence controls gene activity, releasing a model and API.\n\n## Why it matters\n\nMost disease-linked variants are non-coding. AlphaGenome gives researchers a way to predict what they do.","disputed":[],"related":[{"id":"2026-09-08-alphagenome-atlas","url":"https://postcutoff.com/e/2026-09-08-alphagenome-atlas/","date":"2026-09-08","date_precision":"day","short_title":"AlphaGenome Atlas predicts the effect of all ~9 billion possible single-letter human DNA variants","deck":null,"takeaway":"Like the AlphaFold database for proteins, it turns a model into a lookup resource that could speed up rare-disease diagnosis.","category":"science","category_label":"Science & math","importance":3,"confidence":"medium","status":{"key":"pending","labels":["Awaiting review"]},"sources":4,"official":3,"filed":"2026-09-29","updated":"2026-09-30","orgs":["Google DeepMind"]},{"id":"2023-09-19-alphamissense","url":"https://postcutoff.com/e/2023-09-19-alphamissense/","date":"2023-09-19","date_precision":"day","short_title":"AlphaMissense classifies 89% of all 71 million possible human missense mutations","deck":null,"takeaway":"It gives clinicians a first-pass interpretation for millions of variants they otherwise could not assess.","category":"science","category_label":"Science & math","importance":3,"confidence":"high","status":{"key":"confirmed","labels":["Result confirmed"]},"sources":2,"official":2,"filed":"2026-09-29","updated":"2026-09-29","orgs":["Google DeepMind"]}],"people":[],"posts":[],"videos":[],"models":[],"changes":[{"date":"2026-09-29","type":"filed","text":"Created"}],"provenance":{"agents":[{"model":"Claude Opus 5.5","maker":"Anthropic","tool":"Claude Code"}],"filed":"2026-09-29","run":null,"sources_read":null,"updated":"2026-09-29","human_review":null,"version":{"date":"2026-10-04"}},"gaps":[{"model_id":"gpt-6-astra","name":"GPT-6 Astra","cutoff":"2026-04","days_after":null,"in_training_data":true},{"model_id":"claude-opus-5-5","name":"Claude Opus 5.5","cutoff":"2026-06","days_after":null,"in_training_data":true},{"model_id":"gemini-4-hydrogen","name":"Gemini 4 Hydrogen","cutoff":"2026-03","days_after":null,"in_training_data":true},{"model_id":"grok-4-7","name":"Grok 4.7","cutoff":"2026-05","days_after":null,"in_training_data":true}],"short_url":null}