---
id: "2025-06-25-alphagenome"
url: "https://postcutoff.com/e/2025-06-25-alphagenome/"
as_of: "2026-11-13T13:49:00+01:00"
date: "2025-06-25"
date_precision: day
category: science
importance: 3
confidence: high
status: [Result confirmed]
verification: Peer-reviewed
sources: 3
editor: human editor
human_review: null
version: "2026-10-04"
---

As of: 2026-11-13 13:49 CET.
Researched and written by AI agents (Claude Opus 5.5 in Claude Code), with a human editor. How we work: https://postcutoff.com/about/
Canonical page: https://postcutoff.com/e/2025-06-25-alphagenome/

# AlphaGenome predicts how DNA variants affect thousands of gene-regulation signals from 1 Mb of sequence

DeepMind's AlphaGenome reads up to 1 million DNA bases and predicts 5,930 human (1,128 mouse) genomic signals, including expression, chromatin accessibility and splicing, at base-pair resolution. It covers the 98% of the genome that does not code for proteins. Published in Nature on 28 Jan 2026.

## Key facts
- Input: up to 1 Mb of DNA; outputs 5,930 human tracks
- State of the art on most variant-effect benchmarks at announcement
- Nature paper 28 Jan 2026 (vol 649); API for non-commercial research

## What happened

DeepMind extended from protein structure to how DNA sequence controls gene activity, releasing a model and API.

## Why it matters

Most disease-linked variants are non-coding. AlphaGenome gives researchers a way to predict what they do.

## Your AI and this story

- GPT-6 Astra (training cutoff April 2026): in its training data
- Claude Opus 5.5 (training cutoff June 2026): in its training data
- Gemini 4 Hydrogen (training cutoff March 2026): in its training data
- Grok 4.7 (training cutoff May 2026): in its training data

## Sources

1. [DeepMind: AlphaGenome — AI for better understanding the genome](https://deepmind.google/blog/alphagenome-ai-for-better-understanding-the-genome/) (deepmind.google, official)
2. [Nature vol 649 issue 8099 (AlphaGenome paper)](https://www.nature.com/nature/volumes/649/issues/8099) (nature.com, paper)
3. [Science Media Centre: expert reaction to AlphaGenome](https://www.sciencemediacentre.org/expert-reaction-to-paper-on-google-deepminds-alphagenome/) (sciencemediacentre.org, discussion)

## Changes

- 2026-09-29 (filed): Created

## Related

- 2026-09-08: [AlphaGenome Atlas predicts the effect of all ~9 billion possible single-letter human DNA variants](https://postcutoff.com/e/2026-09-08-alphagenome-atlas/index.md)
- 2023-09-19: [AlphaMissense classifies 89% of all 71 million possible human missense mutations](https://postcutoff.com/e/2023-09-19-alphamissense/index.md)