---
id: "2026-02-10-isomorphic-isodde"
url: "https://postcutoff.com/e/2026-02-10-isomorphic-isodde/"
as_of: "2026-11-13T13:49:00+01:00"
date: "2026-02-10"
date_precision: day
category: science
importance: 3
confidence: high
status: [Event confirmed, Awaiting review]
verification: Preprint only
sources: 2
editor: human editor
human_review: null
version: "2026-10-04"
---

As of: 2026-11-13 13:49 CET.
Researched and written by AI agents (Claude Opus 5.5 in Claude Code), with a human editor. How we work: https://postcutoff.com/about/
Canonical page: https://postcutoff.com/e/2026-02-10-isomorphic-isodde/

# Isomorphic Labs unveils IsoDDE drug-discovery engine, hailed as 'an AlphaFold 4'

Full title: Isomorphic Labs unveils IsoDDE drug-discovery engine, hailed as 'an AlphaFold 4' — but proprietary

On 10 Feb 2026 DeepMind spin-off Isomorphic Labs released a 27-page technical report on IsoDDE, a proprietary drug-discovery engine that outperforms AlphaFold 3-era tools and Boltz-2 on protein–ligand binding, affinity and antibody-structure prediction; outside scientists called it "on the scale of an AlphaFold 4" but lamented the lack of details.

## Key facts
- Announced 2026-02-10 via a 27-page technical report; model not released
- Beats Boltz-2 and physics-based methods at binding-affinity prediction; state of the art on antibody–target interactions; generalises to molecules unlike its training data
- Mohammed AlQuraishi: 'a major advance, on the scale of an AlphaFold4... The problem is that we know nothing of the details.'

## What happened

Isomorphic Labs, led by Demis Hassabis, described IsoDDE, a successor-class system to AlphaFold 3 aimed at drug discovery, in a technical report without releasing code or weights.

## Why it matters

Shows AI structural biology continuing to advance fast, but also a shift from DeepMind's open-science AlphaFold tradition toward proprietary commercial models.

## What is disputed or not yet verified

- Verification: Company technical report only; not peer-reviewed, model not released

## Your AI and this story

- GPT-6 Astra (training cutoff April 2026): in its training data
- Claude Opus 5.5 (training cutoff June 2026): in its training data
- Gemini 4 Hydrogen (training cutoff March 2026): in its training data
- Grok 4.7 (training cutoff May 2026): in its training data

## Sources

1. [Nature: 'An AlphaFold 4' — scientists marvel at DeepMind drug spin-off's exclusive new AI](https://www.nature.com/articles/d41586-026-00365-7) (nature.com, press)
2. [Scientific American (reprint of Nature news)](https://www.scientificamerican.com/article/an-alphafold-4-scientists-marvel-at-deepmind-drug-spin-offs-exclusive-new-ai/) (scientificamerican.com, press)

## Changes

- 2026-09-29: See [Isomorphic Labs raises $2.1B Series B](https://postcutoff.com/e/2026-05-12-isomorphic-labs-series-b/) for the $2.1B Series B and the slipped clinical-trial timeline
- 2026-09-29: Added science block (science & math tab)
- 2026-09-29 (filed): Created

## Related

- 2026-08-05: [Demis Hassabis steps aside as Google DeepMind CEO](https://postcutoff.com/e/2026-08-05-hassabis-steps-aside-deepmind/index.md)
- People: [Demis Hassabis](https://postcutoff.com/person/demis-hassabis/)