{"schema":"postcutoff/event@1","as_of":"2026-11-13T13:49:00+01:00","url":"https://postcutoff.com/e/2026-09-08-alphagenome-atlas/","md":"https://postcutoff.com/e/2026-09-08-alphagenome-atlas/index.md","disclosure":{"written_by":"AI agents (Claude Opus 5.5 in Claude Code)","editor":"human editor","policy":"https://postcutoff.com/about/"},"license":null,"id":"2026-09-08-alphagenome-atlas","date":"2026-09-08","date_precision":"day","short_title":"AlphaGenome Atlas predicts the effect of all ~9 billion possible single-letter human DNA variants","deck":null,"takeaway":"On 8 Sep 2026 DeepMind released AlphaGenome Atlas: predictions for all ~9 billion possible single-nucleotide variants in the human genome (~1 PB of data).","category":"science","category_label":"Science & math","importance":3,"confidence":"medium","status":{"key":"pending","labels":["Awaiting review"]},"sources":[{"n":1,"title":"DeepMind: AlphaGenome","url":"https://deepmind.google/blog/alphagenome-ai-for-better-understanding-the-genome/","type":"official","group":"primary","domain":"deepmind.google"},{"n":2,"title":"Google DeepMind: AlphaGenome Atlas: a predictive map of every possible DNA letter change in the human genome","url":"https://deepmind.google/blog/alphagenome-atlas-a-predictive-map-of-every-possible-dna-letter-change-in-the-human-genome/","type":"official","group":"primary","domain":"deepmind.google"},{"n":3,"title":"Google blog: AlphaGenome Atlas","url":"https://blog.google/innovation-and-ai/models-and-research/google-deepmind/alphagenome-atlas/","type":"official","group":"primary","domain":"blog.google"},{"n":4,"title":"Fortune: Google DeepMind AI predictions for 9 billion mutations in the human genome","url":"https://fortune.com/2026/09/08/google-deepmind-ai-predictions-9-billion-mutation-human-genome/","type":"press","group":"press","domain":"fortune.com"}],"official":3,"filed":"2026-09-29","updated":"2026-09-30","orgs":["Google DeepMind"],"title":"AlphaGenome Atlas predicts the effect of all ~9 billion possible single-letter human DNA variants","summary":"On 8 Sep 2026 DeepMind released AlphaGenome Atlas: predictions for all ~9 billion possible single-nucleotide variants in the human genome (~1 PB of data). A new variant-impact score reportedly 'more than doubles' rare-disease variant identification versus the previous standard, and collaborators experimentally confirmed variants in unsolved rare-disease cases.","key_facts":["~9 billion variants, ~1 petabyte of predictions","New AVI score: 'more than doubles' rare-disease variant identification (company claim)","Collaborators verified variants in previously unsolved rare-disease cases"],"key_numbers":[],"tags":["biology","genomics","rare-disease","alphagenome"],"science":{"field":"medicine","subfield":"rare-disease genetics","problem":"Diagnosing rare diseases caused by non-coding variants","result":"Genome-wide variant-effect atlas with claimed doubling of rare-disease variant identification.","open_since":"","ai_system":["AlphaGenome"],"human_role":"Human-designed; clinical collaborators validated cases","verification":{"key":"none","label":"Unverified claim","text":"Technical paper; company-reported benchmarks; some cases lab-validated"},"status":"pending","shock":""},"body_md":"## What happened\n\nDeepMind pre-computed AlphaGenome predictions for every possible single-letter change in the human genome and released them as an atlas for clinicians and researchers.\n\n## Why it matters\n\nLike the AlphaFold database for proteins, it turns a model into a lookup resource that could speed up rare-disease diagnosis.","disputed":[{"label":"Verification","text":"Technical paper; company-reported benchmarks; some cases lab-validated","sources":[]}],"related":[{"id":"2025-06-25-alphagenome","url":"https://postcutoff.com/e/2025-06-25-alphagenome/","date":"2025-06-25","date_precision":"day","short_title":"AlphaGenome predicts how DNA variants affect thousands of gene-regulation signals from 1 Mb of sequence","deck":null,"takeaway":"DeepMind's AlphaGenome reads up to 1 million DNA bases and predicts 5,930 human (1,128 mouse) genomic signals, including expression, chromatin accessibility and splicing, at base-pair resolution.","category":"science","category_label":"Science & math","importance":3,"confidence":"high","status":{"key":"confirmed","labels":["Result confirmed"]},"sources":3,"official":2,"filed":"2026-09-29","updated":"2026-09-29","orgs":["Google DeepMind"]},{"id":"2023-09-19-alphamissense","url":"https://postcutoff.com/e/2023-09-19-alphamissense/","date":"2023-09-19","date_precision":"day","short_title":"AlphaMissense classifies 89% of all 71 million possible human missense mutations","deck":null,"takeaway":"It gives clinicians a first-pass interpretation for millions of variants they otherwise could not assess.","category":"science","category_label":"Science & math","importance":3,"confidence":"high","status":{"key":"confirmed","labels":["Result confirmed"]},"sources":2,"official":2,"filed":"2026-09-29","updated":"2026-09-29","orgs":["Google DeepMind"]}],"people":[],"posts":[],"videos":[{"id":"deepmind-alphagenome-atlas","title":"AlphaGenome Atlas: Understanding the human genome","url":"https://postcutoff.com/v/deepmind-alphagenome-atlas/"},{"id":"two-minute-papers-alphagenome-atlas","title":"DeepMind's New AI Just Cracked The Code Of Life","url":"https://postcutoff.com/v/two-minute-papers-alphagenome-atlas/"}],"models":[],"changes":[{"date":"2026-09-30","type":"edit","text":"Added official DeepMind and Google blog announcement links"},{"date":"2026-09-29","type":"filed","text":"Created"}],"provenance":{"agents":[{"model":"Claude Opus 5.5","maker":"Anthropic","tool":"Claude Code"}],"filed":"2026-09-29","run":null,"sources_read":null,"updated":"2026-09-30","human_review":null,"version":{"date":"2026-10-08"}},"gaps":[{"model_id":"gpt-6-astra","name":"GPT-6 Astra","cutoff":"2026-04","days_after":131,"in_training_data":false},{"model_id":"claude-opus-5-5","name":"Claude Opus 5.5","cutoff":"2026-06","days_after":70,"in_training_data":false},{"model_id":"gemini-4-hydrogen","name":"Gemini 4 Hydrogen","cutoff":"2026-03","days_after":161,"in_training_data":false},{"model_id":"grok-4-7","name":"Grok 4.7","cutoff":"2026-05","days_after":100,"in_training_data":false}],"short_url":null}