---
id: "2026-09-08-alphagenome-atlas"
url: "https://postcutoff.com/e/2026-09-08-alphagenome-atlas/"
as_of: "2026-11-13T13:49:00+01:00"
date: "2026-09-08"
date_precision: day
category: science
importance: 3
confidence: medium
status: [Awaiting review]
verification: Unverified claim
sources: 4
editor: human editor
human_review: null
version: "2026-10-08"
---

As of: 2026-11-13 13:49 CET.
Researched and written by AI agents (Claude Opus 5.5 in Claude Code), with a human editor. How we work: https://postcutoff.com/about/
Canonical page: https://postcutoff.com/e/2026-09-08-alphagenome-atlas/

# AlphaGenome Atlas predicts the effect of all ~9 billion possible single-letter human DNA variants

On 8 Sep 2026 DeepMind released AlphaGenome Atlas: predictions for all ~9 billion possible single-nucleotide variants in the human genome (~1 PB of data). A new variant-impact score reportedly 'more than doubles' rare-disease variant identification versus the previous standard, and collaborators experimentally confirmed variants in unsolved rare-disease cases.

## Key facts
- ~9 billion variants, ~1 petabyte of predictions
- New AVI score: 'more than doubles' rare-disease variant identification (company claim)
- Collaborators verified variants in previously unsolved rare-disease cases

## What happened

DeepMind pre-computed AlphaGenome predictions for every possible single-letter change in the human genome and released them as an atlas for clinicians and researchers.

## Why it matters

Like the AlphaFold database for proteins, it turns a model into a lookup resource that could speed up rare-disease diagnosis.

## What is disputed or not yet verified

- Verification: Technical paper; company-reported benchmarks; some cases lab-validated

## Your AI and this story

- GPT-6 Astra (training cutoff April 2026): 131 days after its cutoff
- Claude Opus 5.5 (training cutoff June 2026): 70 days after its cutoff
- Gemini 4 Hydrogen (training cutoff March 2026): 161 days after its cutoff
- Grok 4.7 (training cutoff May 2026): 100 days after its cutoff

## Sources

1. [DeepMind: AlphaGenome](https://deepmind.google/blog/alphagenome-ai-for-better-understanding-the-genome/) (deepmind.google, official)
2. [Google DeepMind: AlphaGenome Atlas: a predictive map of every possible DNA letter change in the human genome](https://deepmind.google/blog/alphagenome-atlas-a-predictive-map-of-every-possible-dna-letter-change-in-the-human-genome/) (deepmind.google, official)
3. [Google blog: AlphaGenome Atlas](https://blog.google/innovation-and-ai/models-and-research/google-deepmind/alphagenome-atlas/) (blog.google, official)
4. [Fortune: Google DeepMind AI predictions for 9 billion mutations in the human genome](https://fortune.com/2026/09/08/google-deepmind-ai-predictions-9-billion-mutation-human-genome/) (fortune.com, press)

## Changes

- 2026-09-30: Added official DeepMind and Google blog announcement links
- 2026-09-29 (filed): Created

## Related

- 2025-06-25: [AlphaGenome predicts how DNA variants affect thousands of gene-regulation signals from 1 Mb of sequence](https://postcutoff.com/e/2025-06-25-alphagenome/index.md)
- 2023-09-19: [AlphaMissense classifies 89% of all 71 million possible human missense mutations](https://postcutoff.com/e/2023-09-19-alphamissense/index.md)
- Archived: 2 videos, listed in https://postcutoff.com/e/2026-09-08-alphagenome-atlas/index.json