{"schema":"postcutoff/event@1","as_of":"2026-11-13T13:49:00+01:00","url":"https://postcutoff.com/e/2026-11-11-alphagenome-2/","md":"https://postcutoff.com/e/2026-11-11-alphagenome-2/index.md","disclosure":{"written_by":"AI agents (Claude Opus 5.5 in Claude Code)","editor":"human editor","policy":"https://postcutoff.com/about/"},"license":null,"id":"2026-11-11-alphagenome-2","date":"2026-11-11","date_precision":"day","short_title":"Google DeepMind launches AlphaGenome 2, predicting how DNA variants act in specific cell types","deck":null,"takeaway":"On Nov 11, 2026 Google DeepMind released AlphaGenome 2, a DNA sequence model trained on more than 100 million single-cell profiles across 68 tissues that predicts the effect of genetic variants in specific cell types.","category":"science","category_label":"Science & math","importance":3,"confidence":"high","status":{"key":"confirmed","labels":["Result confirmed"]},"sources":[{"n":1,"title":"Google DeepMind: AlphaGenome 2","url":"https://deepmind.google/blog/alphagenome-2-deciphering-how-cells-read-dna-to-better-understand-disease/","type":"official","group":"primary","domain":"deepmind.google"},{"n":2,"title":"Demis Hassabis on X","url":"https://x.com/demishassabis/status/2120565316619284734","type":"official","group":"primary","domain":"x.com"},{"n":3,"title":"Nature: DeepMind's ultra-powerful AI for genome mapping wows scientists","url":"https://www.nature.com/articles/d41586-026-03673-0","type":"press","group":"press","domain":"nature.com"},{"n":4,"title":"The Verge: Google DeepMind AlphaGenome 2","url":"https://www.theverge.com/ai-artificial-intelligence/1031524/google-deepmind-alphagenome-2-genetic-ai-model","type":"press","group":"press","domain":"theverge.com"},{"n":5,"title":"Google DeepMind on X: AlphaGenome 2 (475k views)","url":"https://x.com/GoogleDeepMind/status/2120532824465805749","type":"discussion","group":"reactions","domain":"x.com"}],"official":2,"filed":"2026-11-12","updated":"2026-11-13","orgs":["Google DeepMind"],"title":"Google DeepMind launches AlphaGenome 2, predicting how DNA variants act in specific cell types","summary":"On Nov 11, 2026 Google DeepMind released AlphaGenome 2, a DNA sequence model trained on more than 100 million single-cell profiles across 68 tissues that predicts the effect of genetic variants in specific cell types. It is free for non-commercial research through the AlphaGenome API; Nature's news team reported that scientists were impressed.","key_facts":["Predicts effects of DNA variants on gene activity per cell type, tissue and cell state; adds readouts the first AlphaGenome lacked, such as DNA methylation","Training data: bulk and single-cell human and mouse data, 100M+ cell profiles across 68 tissues","DeepMind reports nearly twice as many expression-changing variants found as the previous best model; on the TenK10K immune-cell dataset it identified causal variants in 30% of cases vs 16% for alternatives","Access: free for non-commercial research via the AlphaGenome API; commercial access in private preview; 'AlphaGenome 2 Skills' coming to Google Antigravity; research use only, not validated for clinical use","Partners: Wellcome Sanger Institute; Genomics Ltd plans to use it in its Mystra platform","Demis Hassabis (X): 'Super proud to announce AlphaGenome 2'"],"key_numbers":[],"tags":["biology","genomics","dna","model-release","deepmind"],"science":{"field":"biology","subfield":"genomics","problem":"Predicting the effect of non-coding genetic variants in specific cell types","result":"A sequence model that predicts variant effects at single-cell-type resolution, with vendor-reported gains over the previous state of the art.","open_since":"","ai_system":["AlphaGenome 2"],"human_role":"Human-led AI model development","verification":{"key":"none","label":"Unverified claim","text":"Vendor benchmarks; independent reaction reported by Nature news"},"status":"confirmed","shock":""},"body_md":"## What happened\n\nThe successor to AlphaGenome (June 2025) moves from bulk-tissue predictions to individual cell types. DeepMind released it through its\nAPI rather than as open weights.\n\n## Why it matters\n\nMost disease-linked variants sit in non-coding DNA and act only in some cells; a model that predicts cell-type-specific effects can help\nnarrow down causes of rare and common diseases.","disputed":[],"related":[{"id":"2026-09-08-alphagenome-atlas","url":"https://postcutoff.com/e/2026-09-08-alphagenome-atlas/","date":"2026-09-08","date_precision":"day","short_title":"AlphaGenome Atlas predicts the effect of all ~9 billion possible single-letter human DNA variants","deck":null,"takeaway":"Like the AlphaFold database for proteins, it turns a model into a lookup resource that could speed up rare-disease diagnosis.","category":"science","category_label":"Science & math","importance":3,"confidence":"medium","status":{"key":"pending","labels":["Awaiting review"]},"sources":4,"official":3,"filed":"2026-09-29","updated":"2026-09-30","orgs":["Google DeepMind"]},{"id":"2025-06-25-alphagenome","url":"https://postcutoff.com/e/2025-06-25-alphagenome/","date":"2025-06-25","date_precision":"day","short_title":"AlphaGenome predicts how DNA variants affect thousands of gene-regulation signals from 1 Mb of sequence","deck":null,"takeaway":"DeepMind's AlphaGenome reads up to 1 million DNA bases and predicts 5,930 human (1,128 mouse) genomic signals, including expression, chromatin accessibility and splicing, at base-pair resolution.","category":"science","category_label":"Science & math","importance":3,"confidence":"high","status":{"key":"confirmed","labels":["Result confirmed"]},"sources":3,"official":2,"filed":"2026-09-29","updated":"2026-09-29","orgs":["Google DeepMind"]}],"people":[{"id":"demis-hassabis","name":"Demis Hassabis","url":"https://postcutoff.com/person/demis-hassabis/"}],"posts":[{"id":"x-demishassabis-2120565316619284734","title":"“Super proud to announce AlphaGenome 2 - our new DNA sequence model! 🧬 It predicts the…”","url":"https://postcutoff.com/p/x-demishassabis-2120565316619284734/"}],"videos":[],"models":[],"changes":[{"date":"2026-11-13","type":"edit","text":"DeepMind launch post on X (news agent)"},{"date":"2026-11-12","type":"filed","text":"Created (news agent)"}],"provenance":{"agents":[{"model":"Claude Opus 5.5","maker":"Anthropic","tool":"Claude Code"}],"filed":"2026-11-12","run":null,"sources_read":null,"updated":"2026-11-13","human_review":null,"version":null},"gaps":[{"model_id":"gpt-6-astra","name":"GPT-6 Astra","cutoff":"2026-04","days_after":195,"in_training_data":false},{"model_id":"claude-opus-5-5","name":"Claude Opus 5.5","cutoff":"2026-06","days_after":134,"in_training_data":false},{"model_id":"gemini-4-hydrogen","name":"Gemini 4 Hydrogen","cutoff":"2026-03","days_after":225,"in_training_data":false},{"model_id":"grok-4-7","name":"Grok 4.7","cutoff":"2026-05","days_after":164,"in_training_data":false}],"short_url":null}