Sam Rodriques

Archived text

The community response to the Millennium Problems for Biology has been great. A few updates:

There is clearly a deep hunger for a more comprehensive list of big unsolved problems in biology and medicine that can serve as a beacon for the field, and we have seen some very good suggestions. Over the next few weeks, FutureHouse will run community-led process to assemble a longer list of grand challenges in biology and will publish this expanded set as additional to the original set, with attribution.

In addition, the Millennium Problem list and specifications also needs to be updated in response to a few issues that people have pointed out. That will happen in the coming days.

Finally, FutureHouse will convene a panel to adjudicate success, and will also announce cash prizes associated with the problems.

We will have more to share soon. Thank you to everyone who has participated in the conversation!

https://x.com/SGRodriques/status/2101449009546273138

Quoting @SGRodriques: In light of the progress in mathematics, we at Edison Scientific and FutureHouse have assembled a set of Millennium Problems for Biology. They are chosen to be very hard to solve but very easy to validate in a simple laboratory environment. Any of these, if solved, would mark a major advance in biotechnology, and most of them would contribute materially towards curing disease. These are, in some sense, the “last reasonable eval” for AI in biology. This was work primarily by @MichaelaThinks and myself, with contributions from many others.

Short descriptions below. The full descriptions of the problems with acceptance criteria are at the Bio Millennium Problems website, linked in the next post. Share more if you have ideas. If they meet our criteria, we’ll add them to our list (with attribution and permission).

views 15726 · likes 153 · reposts 14 · replies 8 (at fetch time)

Archived 2026-10-03 via fxtwitter (unofficial).

The community response to the Millennium Problems for Biology has been great. A few updates:

There is clearly a deep hunger for a more comprehensive list of big unsolved problems in biology and medicine that can serve as a beacon for the field, and we have seen some very good suggestions. Over the next few weeks, FutureHouse will run community-led process to assemble a longer list of grand challenges in biology and will publish this expanded set as additional to the original set, with attribution.

In addition, the Millennium Problem list and specifications also needs to be updated in response to a few issues that people have pointed out. That will happen in the coming days.

Finally, FutureHouse will convene a panel to adjudicate success, and will also announce cash prizes associated with the problems.

We will have more to share soon. Thank you to everyone who has participated in the conversation!

https://x.com/SGRodriques/status/2101449009546273138

Quoting @SGRodriques: In light of the progress in mathematics, we at Edison Scientific and FutureHouse have assembled a set of Millennium Problems for Biology. They are chosen to be very hard to solve but very easy to validate in a simple laboratory environment. Any of these, if solved, would mark a major advance in biotechnology, and most of them would contribute materially towards curing disease. These are, in some sense, the “last reasonable eval” for AI in biology. This was work primarily by @MichaelaThinks and myself, with contributions from many others.

Short descriptions below. The full descriptions of the problems with acceptance criteria are at the Bio Millennium Problems website, linked in the next post. Share more if you have ideas. If they meet our criteria, we’ll add them to our list (with attribution and permission).

views 15726 · likes 153 · reposts 14 · replies 8 (at fetch time)

Archived 2026-10-03 via fxtwitter (unofficial).