Evo 2: a 40B-parameter genome language model trained on DNA from all domains of life
Result confirmed
The takeaway
Arc Institute, Stanford and NVIDIA released Evo 2 (7B and 40B parameters) in Feb 2025, trained on genomes across bacteria, archaea and eukaryotes.
Status
- Claim
Result confirmed
- Our reporting
- High confidence
- Verification
- Peer-reviewed
- Importance
- 3 of 5
- Last verified
- 29 September 2026
Your AI and this story
- GPT-6 AstraIn its training data
- Claude Opus 5.5In its training data
- Gemini 4 HydrogenIn its training data
- Grok 4.7In its training data
It happened before the cutoffs of all four assistants, so it can be in their training data.
Key facts
- Open weights, 7B and 40B parameters, 1M-base context
- Nature publication 4 Mar 2026 (DOI 10.1038/s41586-026-10176-5)
- 88k+ GitHub downloads and 8M+ API requests in its first year, per Arc
What happened
Arc released one of the largest fully open biology models, trained on trillions of DNA bases.
Why it matters
It made genome-scale generative design possible, most notably whole viable bacteriophages.
Sources
2 sources from 2 sites. Numbers match the chips in the text.
2 sources: 1 primary, 1 reaction
Primary
- Arc Institute: Evo 2 one year laterarcinstitute.org, official
Reactions
- Wikipedia: Evo (AI)en.wikipedia.org, discussion
Changes
- Filed